"The general adaptation syndrome is defined as the sum of all non-specific, systemic reactions of the body which ensue upon long continued exposure to stress. The paper calls attention to the possible connection between the adaptation syndrome and various diseases. If this linkage can be proven, the author contends, then it follows that some of the most common fatal diseases of man are due to a breakdown of the hormonal adaptation mechanism." --Hans Selye, C.C., M.D., Ph.D., D. Sc"...it gave the first holistic survey and description of the diseases of adaptation (or 'stress diseases').""The outline of the theory is simple. Agents which derange the normal function of a large number of body cells produce stress reactions in the organism (e.g., burns, strong drugs, temperature extremes, emotion, infection). While these agents may have diverse specific and local effects in the body, they also produce in common general non-specific, systemic reactions. These reactions are attempts of the organism to adapt to stress, or are the byproducts of such attempts. For this reason Selye calls this pattern of reactions the general adaptation syndrome (G.A.S.). The G.A.S. is divided into three stages. First is the alarm reaction in which the organism is in a state of shock. Its body temperature falls, blood sugar rises and then falls, the adrenal and pituitary glands are overactive, and the nervous system is depressed. Most of these changes reverse themselves in a countershock reaction, which develops into the second stage, that called the stage of resistance. In this, the organism develops an increased resistance to the specific stressful agent, but decreases its resistance to all other kinds of stress. Finally, there is the stage of exhaustion, which occurs if the organism is exposed to prolonged stress. Resistance to the stressful agent collapses, and the symptoms of the alarm reaction return. In some cases, non-specific resistance is developed such that the body can withstand other stresses than the one to which it has adapted. Regardless of successful resistance, however, the organism pays for adaptation and may develop what Selye calls diseases of adaptation (e.g., adrenal tumors, vascular lesions, gastrointestinal erosions, rheumatism, arthritis, various psychosomatic disorders, etc.)."----Selye, H., & Foglia, V. G. (1939). On the formation of hemolymph nodes during the alarm reaction. American Journal of Anatomy, 64(1), 133–142. doi:10.1002/aja.1000640106 Selye, H., Collip, J. B., & Thomson, D. L. (1934). Studies on the effect of pregnancy on the ovary. The Anatomical Record, 58(2), 139–143. doi:10.1002/ar.1090580206Selye, H., & McKeown, T. (1934). Further studies on the influence of suckling. The Anatomical Record, 60(3), 323–332. doi:10.1002/ar.1090600307Selye, H. (1939). Effect of muscular exercise on the fat content of the liver. The Anatomical Record, 73(4), 391–400. doi:10.1002/ar.1090730402 Selye, H. (1939). The effect of progesterone on the mouse ovary as influenced by gestation. The Anatomical Record, 75(1), 59–73. doi:10.1002/ar.1090750108 Selye, H. (1940). Postnatal masculinization of the female rat by means of testosterone propionate. The Anatomical Record, 76(2), 145–155. doi:10.1002/ar.1090760204 Selye, H. (1940). Effect of chronic progesterone overdosage on the female accessory sex organs of normal, ovariectomized and hypophysectomized rats. The Anatomical Record, 78(2), 253–271. doi:10.1002/ar.1090780209 Selye, H., Borduas, A., & Masson, G. (1942). Studies concerning the hormonal control of deciduomata and metrial glands. The Anatomical Record, 82(2), 199–209. doi:10.1002/ar.1090820208Clarke, E., Albert, S., & Selye, H. (1942). The influence of various steroids on the development of castration changes in the hypophysis of the rat. The Anatomical Record, 83(3), 449–455. doi:10.1002/ar.1090830312 Selye, H. (1943). Factors influencing development of scrotum. The Anatomical Record, 85(4), 377–385. doi:10.1002/ar.1090850404 Selye, H. (1943). Experiments concerning the mechanism of pituitary colloid secretion. The Anatomical Record, 86(1), 109–119. doi:10.1002/ar.1090860109 Selye, H., & Hall, C. E. (1943). Further studies concerning the action of sodium chloride on the pituitary. The Anatomical Record, 86(4), 579–583. doi:10.1002/ar.1090860408 Selye, H., & Clarke, E. (1944). Ovarian function in hypophysectomized rats. The Anatomical Record, 88(4), 393–402. doi:10.1002/ar.1090880407 Allan, F. D. (1951). On the experimental morphology of the adrenal cortex. By Hans Selye and Helen Stone. 1950. VII + 105 pages. 62 figures. $2/25. Charles C. Thomas, Springfield, Illinois. The Anatomical Record, 109(3), 541–542. doi:10.1002/ar.1091090310 Selye, H. (1958). Sensitization of the skeleton to vitamin-A overdosage by cortisol. Arthritis & Rheumatism, 1(1), 87–90. doi:10.1002/art.1780010113Selye, H., Gentile, G., & Veilleux, R. (1962). An experimental model of calcareous subdeltoid bursitis induced by calciphylaxis. Arthritis & Rheumatism, 5(3), 219–225. doi:10.1002/art.1780050302 Selye, H. (1968). Psyche ? soma. Developmental Psychobiology, 1(1), 71–71. doi:10.1002/dev.420010115 Selye, H. (1943). Morphological changes in the fowl following chronic overdosage with various steroids. Journal of Morphology, 73(3), 401–421. doi:10.1002/jmor.1050730302 Selye, H., Tuchweber, B., & Caruso, P. L. (1965). Drug-Induced Resistance to Tissue Calcification. Journal of Pharmaceutical Sciences, 54(6), 832–837. doi:10.1002/jps.2600540603 The must cells. By Hans Selye. Butterworth, Inc., 7235 Wisconsin Ave., Washington, D. C. 20014, 1965 xxix + 498pp. 17.5 × 25 25cm. price $19.75. (1966). Journal of Pharmaceutical Sciences, 55(5), 540. doi:10.1002/jps.2600550529 Selye, H., Jelinek, J., & Krajny, M. (1969). Prevention of Digitoxin Poisoning by Various Steroids. Journal of Pharmaceutical Sciences, 58(9), 1055–1059. doi:10.1002/jps.2600580903 Selye, H. (1971). Hormones and Resistance. Journal of Pharmaceutical Sciences, 60(1), 1–28. doi:10.1002/jps.2600600102 Kourounakis, P., Szabo, S., Werringloer, J., & Selye, H. (1973). Effect of Various Steroids and ACTH on Plasma Levels of Zoxazolamine and Dicumarol. Journal of Pharmaceutical Sciences, 62(4), 690–692. doi:10.1002/jps.2600620437 Kourounakis, P., Szabo, S., & Selye, H. (1973). Effect of Various Steroids and ACTH on Distribution of Zoxazolamine in Rats. Journal of Pharmaceutical Sciences, 62(12), 1946–1949. doi:10.1002/jps.2600621208 Kourounakis, P., & Selye, H. (1976). Influence of Steroids and Stress on Toxicity and Disposition of Tetraethylammonium Bromide. Journal of Pharmaceutical Sciences, 65(12), 1838–1840. doi:10.1002/jps.2600651236 Grasso, S., & Selye, H. (1962). Calciphylaxis in relation to the humoral production of occlusive coronary lesions with infarction. The Journal of Pathology and Bacteriology, 83(2), 495–500. doi:10.1002/path.1700830222 Selye, H., & Rohan, P. (1966). Prevention of the acute conditioned necrosis phenomenon. Pfl�gers Archiv F�r Die Gesamte Physiologie Des Menschen Und Der Tiere, 291(1), 1–11. doi:10.1007/bf00362648 Selye, H., & Szabo, S. (1972). Protection against haloperidol by catatoxic steroids. Psychopharmacologia, 24(3), 430–434. doi:10.1007/bf00402537 Selye, H., Cantin, M., & Jean, P. (1960). Verh�tung der experimentellen Calcinosis cutis durch Aminoazetonitril (AAN). Archiv F�r Klinische Und Experimentelle Dermatologie, 212(1), 1–7. doi:10.1007/bf00482580 Selye, H., & Tuchweber, B. (1965). Blutungen in entz�ndeten Hautbezirken nach Behandlung mit Antikoagulantien. Archiv F�r Klinische Und Experimentelle Dermatologie, 223(6), 527–532. doi:10.1007/bf00517797 Selye, H. (1970). Protection by catatoxic steroids against cyclophosphamide-induced organ lesions. Virchows Archiv Abteilung A Pathologische Anatomie, 351(3), 248–259. doi:10.1007/bf00543412 Selye, H., & Gentile, G. (1961). Erzeugung calciphylaktischer Speicheldr�senver�nderungen durch Serotonin. Die Naturwissenschaften, 48(21), 671–671. doi:10.1007/bf00592838Selye, H. (1965). Eine durch Serotonin erzeugte Muskeldystrophie. Die Naturwissenschaften, 52(18), 519–519. doi:10.1007/bf00638360 Bajusz, E., & Selye, H. (1960). �ber die durch Stress bedingte Nekroseresistenz des Herzens. Ein Beitrag zum Ph�nomen der ?gekreuzten Resistenz? Die Naturwissenschaften, 47(22), 520–521. doi:10.1007/bf00641129 Selye, H., & Bois, P. (1955). Morphologische Studien �ber den Synergismus zwischen dem somatotrophen Hormon und den Mineralocorticoiden. Virchows Archiv F�r Pathologische Anatomie Und Physiologie Und F�r Klinische Medizin, 327(2), 235–251. doi:10.1007/bf00954979 Bohle, A., Kohler, M., & Burow, H. (1953). Experimentelle Untersuchungen zur ?Endokrinen Niere? (Selye). Virchows Archiv F�r Pathologische Anatomie Und Physiologie Und F�r Klinische Medizin, 323(1), 1–23. doi:10.1007/bf00955333 Selye, H., & Bois, P. (1956). �ber den Einflu� des Thyroxins auf das corticoidbedingte Hyalinosesyndrom. Virchows Archiv F�r Pathologische Anatomie Und Physiologie Und F�r Klinische Medizin, 329(4), 420–432. doi:10.1007/bf00956197 Selye, H., Padmanabhan, N., & Walsh, J. T. (1962). Schutzwirkung der Hypophysektomie gegen�ber der sogenannten ?dystrophischen Gewebsverkalkung? Virchows Archiv F�r Pathologische Anatomie Und Physiologie Und F�r Klinische Medizin, 335(1), 12–20. doi:10.1007/bf00957606 Selye, H., Caruso, P. L., & Tuchweber, B. (1964). Histochemische Studien �ber die Beteiligung der Mastzellen bei der Calciphylaxie. Virchows Archiv F�r Pathologische Anatomie Und Physiologie Und F�r Klinische Medizin, 337(6), 538–546. doi:10.1007/bf00957675 Selye, H., & Bajusz, E. (1959). Erzeugung und Verh�tung von Herznekrosen bei der dehydrotachysterinsensibilisierten Ratte. Virchows Archiv F�r Pathologische Anatomie Und Physiologie Und F�r Klinische Medizin, 332(2), 140–144. doi:10.1007/bf00964219 Selye, H. (1932). Die Sklerodermie und ihre Entstehungsweise. Virchows Archiv Für Pathologische Anatomie Und Physiologie Und Für Klinische Medizin, 286(1), 91–115. doi:10.1007/bf01887242 Collip, J. B., Selye, H., & Thomson, D. L. (1933). Beiträge zur Kenntnis der Physiologie des Gehirnanhanges. Virchows Archiv, 290(1), 23–46. doi:10.1007/bf01979713 Selye, H. (1970). Resistance to picrotoxin poisoning induced by catatoxic steroids. Agents and Actions, 1(3), 133–135. doi:10.1007/bf01982399 Selye, H., Mécs, I., & Szabó, S. (1970). Protection by steroids against acute HgCl2 poisoning. International Urology and Nephrology, 2(3), 287–301. doi:10.1007/bf02081855 Szabo, S. (1985). Half a century of stress research: a tribute to Hans Selye by his students and associates. Experientia, 41(5), 559–578. doi:10.1007/bf02007673 Selye, H., Somogyi, A., & Mécs, I. (1968). Inhibition of local calcergy by topical application of calciphylactic challengers. Calcified Tissue Research, 2(1), 67–76. doi:10.1007/bf02279195 Selye, H. (1930). Studien über vitaminpetente Nahrungsstoffe. Zeitschrift Für Die Gesamte Experimentelle Medizin, 74(1), 320–323. doi:10.1007/bf02624870 Selye, H. (1967). 9. Chirurgie der Nebenniere. Langenbecks Archiv Für Klinische Chirurgie, 319(1), 90–103. doi:10.1007/bf02659240 Effect of Catatoxic Steroids upon Lidocaine IntoxicationSelye, H. (1970). Protection against methyprylon overdosage by catatoxic steroids. Canadian Anaesthetists’ Society Journal, 17(2), 107–111. doi:10.1007/bf03004660Selye, H. (1962). UNIVERSITY OF MONTREAL. Anaesthesia, 17(3), 394–394. doi:10.1111/j.1365-2044.1962.tb13485.x SEYFFARTH, H. (1960). THE CONCEPTION OF “STRESS” AS SUBMITTED BY HANS SELYE. Allergy, 15(6), 532–543. doi:10.1111/j.1398-9995.1960.tb03685.x Selye, H. (1962). EPIDEMIOLOGY OF SKIN DISEASES IN AFRICA. Australasian Journal of Dermatology, 6(3), 217–217. doi:10.1111/j.1440-0960.1962.tb01645.x Selye, H. (1955). ON A SINGULAR OVARIAN CHANGE PRODUCED BY METHYLANDROSTENEDIOL (MAD). BJOG: An International Journal of Obstetrics and Gynaecology, 62(3), 364–366. doi:10.1111/j.1471-0528.1955.tb14150.x Selye, H. (1958). PROTECTION BY PREGNANCY AGAINST THE DEVELOPMENT OF “INFARCTOID CARDIOPATHY” AND NEPHROCALCINOSIS. BJOG: An International Journal of Obstetrics and Gynaecology, 65(4), 588–589. doi:10.1111/j.1471-0528.1958.tb08562.x Bertok, L. (1998). Hans Selye (1907-1982). Annals of the New York Academy of Sciences, 851(1 STRESS OF LIF), xv–xv. doi:10.1111/j.1749-6632.1998.tb08967.x KOVACS, K. (1998). Hans Selye: The Original and Creative Scientista. Annals of the New York Academy of Sciences, 851(1 STRESS OF LIF), 13–15. doi:10.1111/j.1749-6632.1998.tb08970.x SZABO, S. (1998). Hans Selye and the Development of the Stress Concepta: Special Reference to Gastroduodenal Ulcerogenesis. Annals of the New York Academy of Sciences, 851(1 STRESS OF LIF), 19–27. doi:10.1111/j.1749-6632.1998.tb08972.x LESHEM, Y. Y., KUIPER, P. J. C., ERDEI, L., LURIE, S., & PERL-TREVES, R. (1998). Do Selye’s Mammalian “GAS” Concept and “Co-stress” Response Exist in Plants? Annals of the New York Academy of Sciences, 851(1 STRESS OF LIF), 199–208. doi:10.1111/j.1749-6632.1998.tb08994.x CHROUSOS, G. P. (1998). Stressors, Stress, and Neuroendocrine Integration of the Adaptive Response: The 1997 Hans Selye Memorial Lecture. Annals of the New York Academy of Sciences, 851(1 STRESS OF LIF), 311–335. doi:10.1111/j.1749-6632.1998.tb09006.x COLLIP, J. B., SELYE, H., & THOMSON, D. L. (1933). Gonad-Stimulating Hormones in Hypophysectomised Animals. Nature, 131(3298), 56–56. doi:10.1038/131056a0 SELYE, H., THOMSON, D. L., & COLLIP, J. B. (1935). Metaplasia of Uterine Epithelium Produced by Chronic strin Administration. Nature, 135(3402), 65–66. doi:10.1038/135065b0 SELYE, H. (1936). A Syndrome produced by Diverse Nocuous Agents. Nature, 138(3479), 32–32. doi:10.1038/138032a0 SELYE, H. (1938). Adaptation Energy. Nature, 141(3577), 926–926. doi:10.1038/141926a0 SELYE, H. (1941). Pharmacological Classification of Steroid Hormones. Nature, 148(3742), 84–85. doi:10.1038/148084c0 SELYE, H. (1943). AN ATTEMPT AT A NATURAL CLASSIFICATION OF THE STEROIDS. Nature, 151(3841), 662–663. doi:10.1038/151662a0 SELYE, H. (1946). Transformation of the Kidney into an Exclusively Endocrine Organ. Nature, 158(4004), 131–131. doi:10.1038/158131b0 SELYE, H., & TIMIRAS, P. S. (1949). Participation of “Brown Fat” Tissue in the Alarm Reaction. Nature, 164(4174), 745–746. doi:10.1038/164745b0SELYE, H. (1951). An Extra-Adrenal Action of Adrenotropic Hormone. Nature, 168(4265), 149–150. doi:10.1038/168149a0 SELYE, H. (1957). Sensitization by Œstradiol to the Production of Experimental Nephrocalcinosis. Nature, 180(4599), 1420–1421. doi:10.1038/1801420a0 SELYE, H. (1959). Diaphragms for Analysing the Development of Connective Tissue. Nature, 184(4687), 701–703. doi:10.1038/184701a0 SELYE, H., TUCHWEBER, B., & ROHAN, P. (1965). Thromboses in Large Veins and Pulmonary Embolisms induced by Catecholamines or Serotonin. Nature, 208(5013), 900–901. doi:10.1038/208900a0 ----Also see:Szentivanyi, Andor. "The beta adrenergic theory of the atopic abnormality in bronchial asthma." Journal of Allergy 42.4 (1968): 203-232.Gellhorn, E.: Autonomic Imbalance and the Hypothalamus, Minneapolis, 1957, University of Minnesota Press.[MHCHAOS][CLEAN TORTURE][CURTIS P. RICHTER][threat management][enhanced interrogation]----Selye, Hans, Gunnar Heuser, and Alexander Horava. The Physiology and Pathology of Exposure to Stress: A Treatise Based on the Concepts of the General-Adaptation-Syndrome and the Diseases of Adaptation : 5. Annual Report on the Stress : 1955-56. , 1956. Print.Selye, Hans, "Stress without distress", ERIC No. EJ158379, 1977.The Physiology and Pathology of Exposure to Stress. A Treatise Based on the Concept of the General Adaptation Syndrome and the Diseases of Adaptation. Ind Med Gaz. 1952 Sep;87(9):431. PMCID: PMC5191521.Selye, Hans. Annual Report on Stress. New York: MD Publications, 1951. Print.Selye, Hans. The Stress of Life: Book V. New York: McGraw-Hill Book Co, 1956. Print.Kavanagh, Jennifer. Stress and Performance: A Review of the Literature and Its Applicability to the Military. Fort Belvoir, VA: Defense Technical Information Center, 2005. Internet resource.{https://archive.org/details/DTIC_ADA439046}Cohen, Margo P, and Piero P. Foa. The Brain As an Endocrine Organ. New York, NY: Springer New York, 1989. Internet resource.----movies: "Stress," by Selye, Hans, 1907-1982; Balla, Nicholas. pro; MacNeill, Ian. drt; Weintraub, William. aus; Blackburn, Maurice, 1914-1988. cmp; McDonell, Fergus, 1910-1984. flm; National Film Board of Canada; Publication date 1956.https://archive.org/details/stress_20170331Licklider, J. C. R., & Bunch, M. E. (1946). Effects of enforced wakefulness upon the growth and the maze-learning performance of white rats. Journal of Comparative Psychology, 39(6), 339–350. doi:10.1037/h0060623["As a means of enforcing continued muscular activity, a motor-driven revolving cage was an obvious choice, but Bast and Loevenhart (2) had used revolving cages and had found that some of their rabbits had simply gone to sleep and let the apparatus roll them over and over. It was decided, therefore, to try a motor-driven treadmill surrounded by water. If the rats went to sleep, they would be dumped off the end of the treadmill into the water, immersion would awaken them, and they would scramble back onto the treadmill. The treadmill surrounded by water proved to be quite effective as an arrangement for enforcing wakefulness."] {Experiment shown in film: "Stress," NFBC, Selye, 1956.}----Fitzpatrick, Edward A. "Manpower and Atomic War." The ANNALS of the American Academy of Political and Social Science 278.1 (1951): 126-136.["Manpower and [4th Generation (terrorism)]* warfare... reveals what Austria showed clearly, and what such destruction would show --how very uncertain and insecure public power is. It reveals total war, involving all women and all children as well as all men. It reveals a new importance of martial law. The armed forces must always keep in mind that every time they take a man, they are pre-empting an actual or potential worker in war industry."] [*"whatever you call the next kind of war -technological war, machine war, or atomic war."][Nominative Targeting][Target Nomination][Nominating Targets][Joint Targeting]Asymmetric Warfare Group (AWG)Doctrine, Organization, Training, Materiel, Leadership and Education, Personnel and Facilities (DOTMLPF)[United States Army Aviation Center of Excellence (USAACE)][Ft. Rucker]{JP360}"Every target nominated should contribute to attaining the JFC’s objectives."